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The special epitopes in the kidneys can attract the immune complexes, so the immune complexes will flow with blood circulation and deposit in the glomerular capillary loops, which gives rise to segmental hyaline degeneration in the epithelial cells of the glomerulus. As a result, the surface of epithelial cells of the glomerulus is desquamation, and inflammatory mediator continues to invade, leading to the damages of epithelial cells barrier function. Proteins in the blood will run into urine, and then get discharged out of body. Meanwhile, after epithelial cells get damaged, they will turn into myofibroblast, resulting in glomerular sclerosis, and start the process of renal fibrosis.