Cannabidiol (CBD), a major nonpsychotropic constituent of Cannabis, has multiple pharmacological actions, including anxiolytic, antipsychotic, antiemetic and anti-inflammatory properties. However, little is known about its safety and side effect profile in animals and humans. This review describes in vivo and in vitro reports of CBD administration across a wide range of concentrations, based on reports retrieved from Web of Science, Scielo and Medline. The keywords searched were "cannabinoids", "cannabidiol" and "side effects". Several studies suggest that CBD is non-toxic in non-transformed cells and does not induce changes on food intake, does not induce catalepsy, does not affect physiological parameters (heart rate, blood pressure and body temperature), does not affect gastrointestinal transit and does not alter psychomotor or psychological functions. Also, chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans. Conversely, some studies reported that this cannabinoid can induce some side effects, including inhibition of hepatic drug metabolism, alterations of in vitro cell viability, decreased fertilization capacity, and decreased activities of p-glycoprotein and other drug transporters. Based on recent advances in cannabinoid administration in humans, controlled CBD may be safe in humans and animals. However, further studies are needed to clarify these reported in vitro and in vivo side effects.
Los estudios científicos han demostrado que la detección temprana y el tratamiento del glaucoma, antes de que cause pérdida grave de la visión, son la mejor manera de controlar la enfermedad. Si usted se encuentra en uno de los grupos que corren mayor riesgo de tener glaucoma, asegúrese de ir al oculista y hacerse un examen de los ojos que incluya dilatación de las pupilas cada dos años.
Para obtener más información sobre el glaucoma escriba a: ¡Ojo con su visión!, 2020 Vision Place, Bethesda, Maryland 20892-3655, Estados Unidos.
Instituto Nacional del Ojo (NEI)
Institutos Nacionales de la Salud (NIH)
Publicación de los NIH No. 96-3251S
Septiembre de 2001
Given the complexities of treating head and neck cancer, a team approach which utilizes a variety of different specialists is essential to minimizing the complications and maximizing the chances for recovery. In addition to the treating physicians— an oral or ear, nose and throat surgeon, a medical and/or radiation oncologist, a plastic surgeon, prosthodontist, and a dentist among them—a number of other health care professionals can assist with your recovery. These other team members include dietitians, social workers, nurses, physical therapists, and speech-language therapists .