Bufotoxins are a family of toxic steroid lactones . They occur in the parotoid glands , skin and poison of many toads ( genus Bufo ) and other amphibians, and in some plants and mushrooms.    The exact composition varies greatly with the specific source of the toxin. It can contain: 5-MeO-DMT , bufagins , bufalin , bufotalin , bufotenin , bufothionine , epinephrine , norepinephrine , and serotonin . The term bufotoxin can also be used specifically to describe the conjugate of a bufagin with suberylargine. 
Osteoporosis is particularly common in smokers, postmenopausal women, the elderly, underweight or immobile, and patients with diabetes or lung problems. Osteoporosis may result in fractures of the spine, ribs or hip joint with minimal trauma. These occur after the first year in 10–20% of patients treated with more than mg prednisone daily. It is estimated that up to 50% of patients on long-term prednisone will develop bone fractures. Vertebral fractures are more common in patients on steroids, even in those with normal bone density.