Steroid responsive encephalopathy emedicine

Steroid Responsive Meningitis - Samantha Goldberg BVSc MRCVS

Neck Pain and Fever in a Boxer--NAVA Clinician's Brief, November 2009
The Five Minute Veterinary Consult Page 388,
J AM Vet Med Assoc 201[10]:1553-8 Nov 15'92--Systemic Necrotizing Vasculitis in Nine Young Beagles.
J Vet Inter Med 4[2]:112 Mar/Apr'90 ACVIM 8th Annual Forum--Systemic Vasculitis {Canine Pain Syndrome} in young beagles
J Vet Intern Med 2[1]:26-35 Jan/Mar'88 123 Refs--Canine Meningitis:A Changing Emphasis
The Veterinary Record, June 17, 1978--Polyarteritis in a colony of beagles.
The Veterinary Record, April 7th 1973--Polyarteritis in the Dog: A Case Report   Dr. Roughie’s Questions and Answers- Steroid Responsive Meningitis-Vasculitis: The Disease With Many Names   Kasmin D. Bittle DVM   /images/Health/Dr-Roughie-ST-Column/
Neck Pain By Dr. J. E. Dillberger,  /images/Health/Dr-Roughie-ST-Column/

We found reports of 251 patients (median age 52years [range 18-86], 73% females, 80 [32%] with preexisting thyroiditis). Patients presented encephalitis signs with convulsions (n=117; 47%), confusion (n=115, 46%), speech disorder (n=91, 37%), memory impairment (n=107, 43%), gait disturbance (n=67, 27%) and persecutory delusions (n=61, 25%). Twenty-eight patients (11%) presented progressive memory impairment and 26 (10%) isolated psychiatric disorders. In serum, 34% of patients were positive for anti-thyroid peroxidase (TPO) antibodies, 7% for anti-thyroglobulin (TG) antibodies, and 69% both. Thyroid-stimulating hormone levels were usually normal, at 2 UI/ml [-205]. Cerebrospinal fluid from 10/53 patients (19%) was positive for anti-TPO antibodies, 2/53 (4%) anti-TG antibodies and 28 (53%) both. Electroencephalography findings were abnormal for 82% of patients, showing diffuse slowing consistent with encephalopathy (70%) or epileptic activity (14%). The first-line treatment was steroids in 193 patients and other immunosuppressive drugs in 10 cases. At a median follow-up of 12months [range -110], 91% of patients showed complete or partial neurological response, with anti-TPO and -TG antibody titers at 347 UI/ml [0-825,000] and 110 UI/ml [0-50,892], respectively. During follow-up, 40 patients (16%) experienced at least one relapse. Relapse was more frequent in patients with initial coma (26% vs 13%, p=).

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Steroid responsive encephalopathy emedicine

steroid responsive encephalopathy emedicine

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