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I pin 2 iu daily the first week and could feel something but chalked it up to placebo. Bumped it to 3iu on MWF and 4 on Tuesday/Thursday and that when typical sides kicked in. My hands are already weighing me down but now they are like bricks sometimes. I have slight carpel, but the good outweighs the bad. Skin has improved hair no longer being considered a total loss, nails look prime for biting, and my favorite, the sleep. My sleep is great. Taking addiction meds makes difficult to fall asleep, but that hasn't been case since week 3. I'm in my 6th week now and feel great as the fat starts to come off for my transformation. For GH I am mainly concerned with overall well being than fat loss. I may lower the Tues/Thursday dose to 3iu. I've taken Humatrope throughout my usage, and while this isnt exactly equal, for the money it's my new go to.