Topical non-steroidal anti-inflammatory drugs a review of their use and toxicity

Severe: Medical management of severe doxepin overdosage consists of aggressive supportive therapy. The area covered with doxepin HCI cream should be thoroughly washed. An adequate airway should be established in comatose patients and assisted ventilation used if necessary. EKG monitoring may be required for several days, because relapse after apparent recovery has been reported with oral doxepin HCI. Arrhythmias should be treated with the appropriate antiarrhythmic agent. It has been reported that many of the cardiovascular and CNS symptoms of tricyclic antidepressant poisoning in adults may be reversed by the slow intravenous administration of 1 mg to 3 mg of physostigmine salicylate. Because physostigmine is rapidly metabolized, the dosage should be repeated as required. Convulsions may respond to standard anticonvulsant therapy; however, barbiturates may potentiate any respiratory depression. Dialysis and forced diuresis generally are not of value in the management of overdosage due to high tissue and protein binding of doxepin HCI.

Distributed by:  Alpharma Pharmaceuticals LLC
                         One New England Avenue, Piscataway, NJ 08854 USA
                         (Telephone:1-888-840-8884) •
Manufactured for:  IBSA Institut Biochimique SA, CH-6903 Lugano, Switzerland
Manufactured by:  Teikoku Seiyaku Co., Ltd., Sanbonmatsu, Kagawa 769-2695 Japan

Apply to the affected area and massage into the skin gently. Always wash your hands after you have finished rubbing the cream, gel or spray into the skin. This is to make sure that you avoid rubbing this medicine into sensitive areas of the body such as the eyes. Do not apply to skin that is broken, or near the eyes, nose, mouth, genital or bottom (anal) areas. Do not use plasters or bandages (dressings) on top of these medicines. Generally these medicines are applied to the skin 2-4 times a day. However, for specific advice for your medicine, see the leaflet that comes inside the packet.

How can you protect your pet?
If you use a topical pain relief product, it’s critical to keep these medications away from your dog or cat. If you apply a topical cream or lotion, avoid touching your pet for several hours and only after thoroughly washing. Be careful contacting couches, chairs and bedding with these preparations. Curious cats and dogs may lick residues and become poisoned. Cats may be affected by tiny amounts of flurbiprofen and there may be risk of continued exposure to tiny amounts over several days or weeks.  

Veterinarians have been seeing an increase in inadvertent poisonings from topical medications over the past several years. Hormone and testosterone gels, cancer medications, nicotine patches, topical steroids and pain treatments have all been reported to cause accidental toxicity in pets. This latest FDA warning reminds us that as we seek convenience and relief for ourselves, there may be unintended consequences for our pets. Treat your pain, but remember even our most seemingly safe medications may be deadly to our furry family members.

Click here for 5 things you should never assume are safe for pets.

Topical non-steroidal anti-inflammatory drugs a review of their use and toxicity

topical non-steroidal anti-inflammatory drugs a review of their use and toxicity

How can you protect your pet?
If you use a topical pain relief product, it’s critical to keep these medications away from your dog or cat. If you apply a topical cream or lotion, avoid touching your pet for several hours and only after thoroughly washing. Be careful contacting couches, chairs and bedding with these preparations. Curious cats and dogs may lick residues and become poisoned. Cats may be affected by tiny amounts of flurbiprofen and there may be risk of continued exposure to tiny amounts over several days or weeks.  

Veterinarians have been seeing an increase in inadvertent poisonings from topical medications over the past several years. Hormone and testosterone gels, cancer medications, nicotine patches, topical steroids and pain treatments have all been reported to cause accidental toxicity in pets. This latest FDA warning reminds us that as we seek convenience and relief for ourselves, there may be unintended consequences for our pets. Treat your pain, but remember even our most seemingly safe medications may be deadly to our furry family members.

Click here for 5 things you should never assume are safe for pets.

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